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Article

Nonlinear relationship between high-density lipoprotein cholesterol and cardiovascular disease: an observational and Mendelian randomization analysis.

Metabolism: clinical and experimental - 1 May 2024

Chen Jun-Xiang, Li Yue, Zhang Yan-Bo, Wang Yi, Zhou Yan-Feng, Geng Tingting, Liu Gang, Pan An, Liao Yun-Fei

Abstract excerpt

BACKGROUND: Clinical trials and Mendelian randomization (MR) studies reported null effects of high-density lipoprotein cholesterol (HDL-C) on risk of cardiovascular disease (CVD), which might have overlooked a nonlinear causal association. We aimed to investigate the dose-response relationship between circulating HDL-C concentrations and CVD in observational and MR frameworks. METHODS: We included 348,636...

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Identifiers

PMID: 38364900
DOI: 10.1016/j.metabol.2024.155817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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