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Suppression of MR1 by human cytomegalovirus inhibits MAIT cell activation

10 Feb 2023

Abstract excerpt

Introduction: The antigen presentation molecule MHC class I related protein-1 (MR1) is best characterized by its ability to present bacterially derived metabolites of vitamin B2 biosynthesis to mucosal-associated invariant T-cells (MAIT cells). Methods: Through in vitro human cytomegalovirus (HCMV) infection in the presence of MR1 ligand we investigate the modulation of MR1 expression. Using...

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Identifiers

PMID: 36845106
DOI: 10.3389/fimmu.2023.1107497

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