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Article

Putting BASIL in a BLT: A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations.

PLoS computational biology - 1 Feb 2026

Kuo Huan-Yu, Kryazhimskiy Sergey

Abstract excerpt

The distribution of fitness effects (DFE) of new beneficial mutations is a key quantity that dictates the dynamics of adaptation. The barcode lineage tracking (BLT) approach is an important advance toward measuring DFEs. BLT experiments enable researchers to track the frequencies of ~105 barcoded lineages in large microbial populations and detect up to thousands of nascent beneficial mutations in a single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41758887
DOI: 10.1371/journal.pcbi.1013946
PMCID: PMC12974954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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