The fates of mutant lineages and the distribution of fitness effects of beneficial mutations in laboratory budding yeast populations.

Abstract excerpt

The outcomes of evolution are determined by which mutations occur and fix. In rapidly adapting microbial populations, this process is particularly hard to predict because lineages with different beneficial mutations often spread simultaneously and interfere with one another's fixation. Hence to predict the fate of any individual variant, we must know the rate at which new mutations create competing lineages of...

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