Article
Beyond genome sequencing: lineage tracking with barcodes to study the dynamics of evolution, infection, and cancer.
Genomics - 1 Dec 2014
Blundell Jamie R, Levy Sasha F
Abstract excerpt
Evolving cellular communities, such as the gut microbiome, pathogenic infections, and cancer, consist of large populations of ~10(7)-10(14) cells. Because of their large population sizes, adaptation within these populations can be driven by many beneficial mutations that never rise above extremely low frequencies. Genome sequencing methods such as clonal, single cell, or whole population sequencing are poorly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.