Article

Profiling the initial burst of beneficial genetic diversity in clonal cell populations to anticipate evolution

2020-07-10

Abstract excerpt

Clonal populations of cells continuously evolve new genetic diversity, but it takes a significant amount of time for the progeny of a single cell with a new beneficial mutation to outstrip both its ancestor and competitors to fully dominate a population. If these driver mutations can be discovered earlier—while they are still extremely rare—and profiled in large numbers, it may be possible to anticipate the future...

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Literature Corpus work: f22df408-27d8-5ffe-92be-2ce424e66327
DOI: 10.1101/2020.07.10.196832

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