Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.

Molecular and cellular biology - 1 Jul 1992

Patel D, Butler J S

Abstract excerpt

Maturation of most eukaryotic mRNA 3' ends requires endonucleolytic cleavage and polyadenylation of precursor mRNAs. To further understand the mechanism and function of mRNA 3' end processing, we identified a temperature-sensitive mutant of Saccharomyces cerevisiae defective for polyadenylation. Genetic analysis showed that the polyadenylation defect and the temperature sensitivity for growth result from a single...

Topics

Cloning, Molecular
DNA Mutational Analysis
Mutation
Pancreatitis-Associated Proteins
Polynucleotide Adenylyltransferase
Protein Biosynthesis
RNA, Messenger
Saccharomyces cerevisiae
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 1620131
DOI: 10.1128/mcb.12.7.3297-3304.1992
PMCID: PMC364543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1620131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.PMID 1620131Read ↗

A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor.Semantic proximity Read ↗

Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation.Semantic proximity Read ↗

Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.Semantic proximity Read ↗

A nuclear 3'-5' exonuclease involved in mRNA degradation interacts with Poly(A) polymerase and the hnRNA protein Npl3p.Semantic proximity Read ↗

Mutations in the middle domain of yeast poly(A) polymerase affect interactions with RNA but not ATP.Semantic proximity Read ↗

RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor.Semantic proximity Read ↗

Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana.Semantic proximity Read ↗

Six novel genes necessary for pre-mRNA splicing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Coupling of termination, 3' processing, and mRNA export.Semantic proximity Read ↗

Conditional mutants of the yeast mRNA capping enzyme show that the cap enhances, but is not required for, mRNA splicing.Semantic proximity Read ↗

Positive and negative regulation of poly(A) nuclease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.