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Mapping Attenuation Determinants in Enterovirus-D68

8 Aug 2020

Abstract excerpt

Enterovirus (EV)-D68 has been associated with epidemics in the United Sates in 2014, 2016 and 2018. This study aims to identify potential viral virulence determinants. We found that neonatal type I interferon receptor knockout mice are susceptible to EV-D68 infection via intraperitoneal inoculation and were able to recapitulate the paralysis process observed in human disease. Among the EV-D68 strains tested,...

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PMID: 32784424
DOI: 10.3390/v12080867

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