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Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model.

Antiviral research - 1 Jan 2017

Xu Yi, Ma Shuzhi, Zhu Limeng, Huang Zhiqiu, Chen Liyun, Xu Yuhua, Yin Haibin, Peng Tao, Wang Yi

Abstract excerpt

The Enterovirus A71 (EV-A71) subgenogroup C4 is prevalent in China. EV-A71 causes hand, foot and mouth disease (HFMD) in children and may lead to severe neurological diseases. The development of antiviral and protective vaccines against EV-A71 is significantly hindered by the lack of suitable animal models to recapitulate human neurological symptoms. In this study, GZ-CII, a highly virulent EV-A71 subgenogroup C4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27864074
DOI: 10.1016/j.antiviral.2016.11.008

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