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Article

Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection.

Science translational medicine - 30 Oct 2019

Gunaseelan Saravanan, Wong Kai Zhi, Min Nyo, Sun Jialei, Ismail Nur Khairiah Binte Mohd, Tan Yee Joo, Lee Regina Ching Hua, Chu Justin Jang Hann

Abstract excerpt

Human enterovirus A71 (HEVA71) causes hand, foot, and mouth disease (HFMD) in young children and is considered a major neurotropic pathogen but lacks effective antivirals. To identify potential therapeutic agents against HFMD, we screened a 502-compound flavonoid library for compounds targeting the HEVA71 internal ribosome entry site (IRES) that facilitates translation of the HEVA71 genome and is vital for the...

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PMID: 31666401
DOI: 10.1126/scitranslmed.aar5759

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