Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity.

doi:10.1016/j.virol.2009.03.012

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Article

Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity.

Virology - 20 Jun 2009

Sean Polen, Nguyen Joseph H C, Semler Bert L

Abstract excerpt

Coxsackievirus B3 (CVB3) is a causative agent of viral myocarditis, meningitis, pancreatitis, and encephalitis. Much of what is known about the coxsackievirus intracellular replication cycle is based on the information already known from a well-studied and closely related virus, poliovirus. Like that of poliovirus, the 5' noncoding region (5' NCR) of CVB3 genomic RNA contains secondary structures that function in...

Topics

5' Untranslated Regions
Base Sequence
Binding Sites
Coxsackievirus Infections
Electrophoretic Mobility Shift Assay
Enterovirus B, Human
HeLa Cells
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nucleic Acid Conformation

Peptide Chain Initiation, Translational

Poly C

Protein Footprinting

RNA, Viral

RNA-Binding Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19446305
DOI: 10.1016/j.virol.2009.03.012
PMCID: PMC2694229

Genes

PCBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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