The Interplay of Genetics and Lifestyle in MASLD: Focus on LPIN1 rs13412852 and Sedentary Behaviour.

doi:10.3390/ijms27041644

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Article

The Interplay of Genetics and Lifestyle in MASLD: Focus on LPIN1 rs13412852 and Sedentary Behaviour.

International journal of molecular sciences - 8 Feb 2026

Franco Isabella, Donghia Rossella, Bianco Antonella, Bagnato Claudia Beatrice, Verrelli Nicola, Bonfiglio Caterina, Di Nicola Elisabetta, Forte Giovanna, Lepore Signorile Martina, Latrofa Marialaura, D'Addabbo Marika, De Marco Katia, Disciglio Vittoria, Sanese Paola, Giannelli Gianluigi, Fasano Candida, Simone Cristiano, Grossi Valentina

Abstract excerpt

The LPIN1 rs13412852 variant has been linked to lipid levels and liver disease in children. This genotype may modulate the liver's response to sedentary behaviour, potentially increasing the vulnerability of certain individuals to liver dysfunction. These findings underscore the need to consider both genetic predisposition and environmental exposures when evaluating disease risk. This study aims to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41751781
DOI: 10.3390/ijms27041644
PMCID: PMC12940340

Genes

LPIN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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