Article

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease

2024-02-06

Abstract excerpt

<title>Abstract</title> <p>Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses an excess of triglycerides in the liver, which can lead to cirrhosis and liver cancer. While there is solid epidemiological evidence of MASLD coexisting with cardiometabolic disease, several leading genetic risk factors for MASLD do not increase the risk of cardiovascular disease, suggesting no causal relations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89f4252b-5b87-56f0-b2c0-e4cba1540c87
DOI: 10.21203/rs.3.rs-3878807/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver diseaseDOI 10.21203/rs.3.rs-3878807/v1Read

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease.Semantic proximity Read

Human genetics of steatotic liver disease: insights into insulin resistance and lipid metabolism.Semantic proximity Read

Cross-trait genomic modeling reveals the polygenic architecture and systemic impact of MASLD.Semantic proximity Read

Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes.Semantic proximity Read

Cardiometabolic phenotype linked to fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease.Semantic proximity Read

Human genetics of metabolic dysfunction–associated steatotic liver disease: from variants to cause to precision treatmentSemantic proximity Read

Hepatic Lipoprotein Production, Cardiometabolic Phenotypes, and Subtypes of Steatotic Liver Disease.Semantic proximity Read

Genetic Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease.Semantic proximity Read

Early Insights from Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Patients: An Observational Study on Polygenic Risk and Liver BiomarkersSemantic proximity Read

A Polygenic Risk Score to Refine Risk Stratification and Prediction for Severe Liver Disease by Clinical Fibrosis ScoresSemantic proximity Read

Novel subtypes of metabolic associated steatotic liver disease linked to clinical outcomes: implications for precision medicine.Semantic proximity Read

Genetics of Metabolic Dysfunction-associated Steatotic Liver Disease: The State of the Art Update.Semantic proximity Read