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Genetic risk amplifies lifestyle effects on hepatic steatosis and its progression: Insights from a population-based cohort.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Apr 2025

Zhang Xin, Wang Haili, Guo Chengnan, Zhao Shuzhen, Li Yi, Liu Zhenqiu, Zhang Tiejun

Abstract excerpt

BACKGROUND: Steatotic liver disease (SLD) is influenced by both genetics and lifestyle factors, with lifestyle effects varying by genetic susceptibility. We aimed to evaluate gene-lifestyle interactions on SLD risk. METHODS: We included 28,215 UK Biobank participants with available data. Predictors were healthy lifestyle patterns, PNPLA3-rs738409, TM6SF2-rs58542926, a 16-variant hepatic steatosis polygenic risk...

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Source

Identifiers

PMID: 39837741
DOI: 10.1016/j.dld.2025.01.040

Genes

PNPLA3
TM6SF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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