Article
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease.
Nature medicine - 1 Dec 2024
Jamialahmadi Oveis, De Vincentis Antonio, Tavaglione Federica, Malvestiti Francesco, Li-Gao Ruifang, Mancina Rosellina M, Alvarez Marcus, Gelev Kyla, Maurotti Samantha, Vespasiani-Gentilucci Umberto, Rosendaal Frits Richard, Kozlitina Julia, Pajukanta Päivi, Pattou François, Valenti Luca, Romeo Stefano
Abstract excerpt
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by an excess of lipids, mainly triglycerides, in the liver and components of the metabolic syndrome, which can lead to cirrhosis and liver cancer. While there is solid epidemiological evidence that MASLD clusters with cardiometabolic disease, several leading genetic risk factors for MASLD do not increase the risk of cardiovascular...
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