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Article

Single-cell transcriptomics reveals phenotypic and functional alterations of erythroid progenitor cells in tuberculosis patients.

Tuberculosis (Edinburgh, Scotland) - 1 Mar 2026

Zhang Hao, Cao Yan, Yang Ling, Liu Bowen, Guan Jingzhi, Wang Xinjing

Abstract excerpt

Anemia is a common complication of tuberculosis (TB), closely associated with impaired host immune function and poor prognosis; however, its impact on the dynamic alterations of erythroid progenitor cells (EPCs) remains largely unexplored. In this study, we integrated and analyzed single-cell transcriptomic data from peripheral blood mononuclear cells (PBMC) of healthy controls, latent tuberculosis (LTB), TB, and...

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Source

Identifiers

PMID: 41734583
DOI: 10.1016/j.tube.2026.102746

Genes

LTB
CCL5
CHI3L1
GRIK3
GZMA
IFITM3
IL32
JUN
MDK
MIF
S100B
ZDHHC19

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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