Article

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosis

2022-06-11

Abstract excerpt

Mycobacterium tuberculosis ( M.tb ) causes tuberculosis (TB) and remains one of the leading causes of mortality due to an infectious pathogen. Host immune responses have been implicated in driving the progression from infection to severe lung disease. We analyzed longitudinal RNA sequencing (RNAseq) data from the whole blood of 74 TB progressors whose samples were grouped into four six-month intervals preceding d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0998a871-d7d5-5f4a-9a11-47352c799747
DOI: 10.1101/2022.06.10.495597

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neutrophil degranulation, NETosis and platelet degranulation pathway genes are co-induced in whole blood up to six months before tuberculosis diagnosisDOI 10.1101/2022.06.10.495597Read

Whole transcriptome sequencing reveals neutrophils’ transcriptional landscape associated with active tuberculosisSemantic proximity Read

Investigating neutrophil cell death in TB pathogenesisSemantic proximity Read

Major Contribution of Myeloid Cells In TB specific Host Gene Signature: Revelations from Re-Analysis of Publicly Available DatasetsSemantic proximity Read

Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent TuberculosisSemantic proximity Read

Peripheral blood cellular dynamics during the progression of human tuberculosisSemantic proximity Read

Airway immune signatures of protection and disease progression in recent human tuberculosis household contactsSemantic proximity Read

Single-cell transcriptomics of blood identified IFIT1 neutrophil subcluster expansion in NTM-PD patientsSemantic proximity Read

Computational reassessment of RNA-seq data reveals key genes in active tuberculosisSemantic proximity Read

Distinct features of human myeloid cell cytokine response profiles identify neutrophil activation by cytokines as a prognostic feature during tuberculosis and cancer1Semantic proximity Read

Monocyte transcriptome signatures of inflammation and enhanced neutrophil recruitment characterize immunopathology in the blood of tuberculosis patientsSemantic proximity Read

Unravelling the transcriptome of the human tuberculosis lesion and its clinical implicationsSemantic proximity Read

Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosisSemantic proximity Read