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Single-cell transcriptome analysis reveals the dysregulated monocyte state associated with tuberculosis progression

12 Feb 2025

Abstract excerpt

BACKGROUND: In tuberculosis (TB) infection, monocytes play a crucial role in regulating the balance between immune tolerance and immune response through various mechanisms. A deeper understanding of the roles of monocyte subsets in TB immune responses may facilitate the development of novel immunotherapeutic strategies and improve TB prevention and treatment. METHODS: We retrieved and processed raw single-cell...

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PMID: 39939918
DOI: 10.1186/s12879-025-10612-3

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