Single-cell transcriptome sequencing reveals altered peripheral blood immune cells in patients with severe tuberculosis

Abstract excerpt

Tuberculosis is a serious global health burden, resulting in millions of deaths each year. Several circulating cell subsets in the peripheral blood are known to modulate the host immune response to Mycobacterium tuberculosis ( Mtb ) infection in different ways. However, the characteristics and functions of these subsets to varying stages of tuberculosis infection have not been well elucidated. Peripheral blood...