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Article

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.

The Journal of experimental medicine - 26 Sept 2011

Xu Dan, Liu Xia, Yu Wen-Mei, Meyerson Howard J, Guo Caiying, Gerson Stanton L, Qu Cheng-Kui

Abstract excerpt

Activating mutations in protein tyrosine phosphatase 11 (Ptpn11) have been identified in childhood acute leukemias, in addition to juvenile myelomonocytic leukemia (JMML), which is a myeloproliferative disorder (MPD). It is not clear whether activating mutations of this phosphatase play a causal role in the pathogenesis of acute leukemias. If so, the cell origin of leukemia-initiating stem cells (LSCs) remains to...

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Identifiers

PMID: 21930766
DOI: 10.1084/jem.20110450
PMCID: PMC3182060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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