Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia.

doi:10.1182/bloodadvances.2021004631

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Article

Impact of PTPN11 mutations on clinical outcome analyzed in 1529 patients with acute myeloid leukemia.

Blood advances - 14 Sept 2021

Stasik Sebastian, Eckardt Jan-Niklas, Kramer Michael, Röllig Christoph, Krämer Alwin, Scholl Sebastian, Hochhaus Andreas, Crysandt Martina, Brümmendorf Tim H, Naumann Ralph, Steffen Björn, Kunzmann Volker, Einsele Hermann, Schaich Markus, Burchert Andreas, Neubauer Andreas, Schäfer-Eckart Kerstin, Schliemann Christoph, Krause Stefan, Herbst Regina, Hänel Mathias, Frickhofen Norbert, Noppeney Richard, Kaiser Ulrich, Baldus Claudia D, Kaufmann Martin, Rácil Zdenek, Platzbecker Uwe, Berdel Wolfgang E, Mayer Jiri, Serve Hubert, Müller-Tidow Carsten, Ehninger Gerhard, Bornhäuser Martin, Schetelig Johannes, Middeke Jan M, Thiede Christian

Abstract excerpt

The tyrosine-protein phosphatase nonreceptor type 11 (PTPN11) is an important regulator of RAS signaling and frequently affected by mutations in patients with acute myeloid leukemia (AML). Despite the relevance for leukemogenesis and as a potential therapeutic target, the prognostic role is controversial. To investigate the prognostic impact of PTPN11 mutations, we analyzed 1529 adult AML patients using...

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Identifiers

PMID: 34459887
DOI: 10.1182/bloodadvances.2021004631
PMCID: PMC8525221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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