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Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis.

Blood - 30 Apr 2009

Chan Gordon, Kalaitzidis Demetrios, Usenko Tatiana, Kutok Jeffery L, Yang Wentian, Mohi M Golam, Neel Benjamin G

Abstract excerpt

PTPN11, which encodes the tyrosine phosphatase SHP2, is mutated in approximately 35% of patients with juvenile myelomonocytic leukemia (JMML) and at a lower incidence in other neoplasms. To model JMML pathogenesis, we generated knockin mice that conditionally express the leukemia-associated mutant Ptpn11(D61Y). Expression of Ptpn11(D61Y) in all hematopoietic cells evokes a fatal myeloproliferative disorder (MPD),...

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Identifiers

PMID: 19179468
DOI: 10.1182/blood-2008-10-182626
PMCID: PMC2676094

Genes

PTPN11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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