Article
PTPN11 mutations in adult acute myeloid leukaemia: Prevalence and clinical implications in the context of NPM1 mutation.
Leukemia research - 1 Jul 2022
Liu Jie, Qin Wei, Wang Biao, Wang Zheng, Hua Haiying, Zhou Feng, Jia Zhuxia, Wu Pin, Chao Hongying, Lu Xuzhang
Abstract excerpt
More than 90% of NPM1-mutated acute myeloid leukaemia (NPM1mut AML) patients have been determined to harbour other known concurrent mutations. However, there is limited data on the frequency of PTPN11 and its clinical impact in NPM1mut AML. Next-generation sequencing(NGS) was performed retrospectively on 112 genes in 254 patients with NPM1mut AML. Overall, 33 PTPN11 mutations were detected in 29 of the 254...
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