Article
Association of HLA class II (-DRB1,-DQB1,-DPB1) alleles and haplotypes on susceptibility to aplastic anemia in northern Chinese Han.
Human immunology - 1 Dec 2020
Qi Jun, Wang Tian-Ju, Li Heng-Xin, Wu Di, Du Dan, Wu Jun-Hua, Shang Li-Xia, Chen Le, Wang Man-Ni, Wang Xiao-Fang
Abstract excerpt
The Human Leukocyte Antigen (HLA) genes, playing key roles in mediating the immune response, especially HLA class II alleles were suggested to play a role in the activation of autoreactive T-cells in aplastic anemia (AA). Previous studies in different ethnic groups have indicated that some of HLA-A,-B,-DRB1 alleles had a protective or susceptive association with the prevalence, pathogenesis and development of AA....
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