Article
AKT1 but not AKT2 single nucleotide polymorphisms are associated with the risk of microscopic polyangiitis.
PeerJ - 1 Jan 2026
Li Lizhen, Tan Huifang, Peng You, Chu Liepeng, Yang Jing, Tang Wenlv, Tan Kui, Fu Shuangshuang, Huang Meili, Xu Meijun, Rao Jinlan, Xue Chao, Chen Yinyin
Abstract excerpt
Background: Microscopic polyangiitis (MPA), a severe antineutrophil cytoplasmic antibody associated vasculitis (ANCA-associated vasculitis, AAV), demonstrates strong clinical association with myeloperoxidase/perinuclear anti-neutrophilic cytoplasmic antibodies (MPO/P-ANCA). While genetic factors are known to contribute to MPA susceptibility, the potential roles of AKT signaling components remain incompletely...
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