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Article

Association of tyrosine kinase 2 polymorphisms with susceptibility to microscopic polyangiitis in a Guangxi population.

PeerJ - 1 Jan 2024

Yang Binglan, Chu Liepeng, Feng Fei, Lu Shurong, Xue Chao

Abstract excerpt

Background: Heredity and epigenetics affect the pathogenesis of microscopic polyangiitis (MPA). Tyrosine kinase 2 (TYK2) polymorphisms (rs2304256C > A, rs280519A > G, and rs12720270G > A) may be potential protective factors against anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Current research suggests that TYK2 is associated with various autoimmune diseases; however, no study has...

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Identifiers

PMID: 39726748
DOI: 10.7717/peerj.18735
PMCID: PMC11670758

Genes

TYK2

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