Article
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.
Nature communications - 12 Nov 2019
Lyons Paul A, Peters James E, Alberici Federico, Liley James, Coulson Richard M R, Astle William, Baldini Chiara, Bonatti Francesco, Cid Maria C, Elding Heather, Emmi Giacomo, Epplen Jörg, Guillevin Loïc, Jayne David R W, Jiang Tao, Gunnarsson Iva, Lamprecht Peter, Leslie Stephen, Little Mark A, Martorana Davide, Moosig Frank, Neumann Thomas, Ohlsson Sophie, Quickert Stefanie, Ramirez Giuseppe A, Rewerska Barbara, Schett Georg, Sinico Renato A, Szczeklik Wojciech, Tesar Vladimir, Vukcevic Damjan, Terrier Benjamin, Watts Richard A, Vaglio Augusto, Holle Julia U, Wallace Chris, Smith Kenneth G C
Abstract excerpt
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a...
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