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Article

Genetic burden across core genes of the PI3K-AKT-mTOR pathway is associated with susceptibility to microscopic polyangiitis: a Chinese cohort study.

Frontiers in immunology - 1 Jan 2026

Li Lizhen, Yang Jing, Xue Chao, Chu Liepeng, Zhong Huan, Rao Jinlan, She Chang, Tan Lijuan, Fang Xi, Shen Shaoxia, Chen Yinyin

Abstract excerpt

Background: The PI3K-AKT-mTOR signaling pathway plays a central role in immune regulation and has been implicated in autoimmune diseases. However, the contribution of genetic variation within key components of this pathway to microscopic polyangiitis (MPA) remains incompletely understood. Methods: We conducted a genetic association study in a Chinese cohort including MPA patients and controls. Four single...

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Identifiers

PMID: 42112355
DOI: 10.3389/fimmu.2026.1807517
PMCID: PMC13149408

Genes

AKT1
MTOR
PIK3CA
MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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