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Article

APOE Genotype-Stratified Meta-Analysis of Cognitive Decline Reveals Novel Loci for Language and Global Cognitive Function in Older Adults.

International journal of molecular sciences - 19 Jul 2025

Acharya Vibha, Fan Kang-Hsien, Snitz Beth E, Ganguli Mary, DeKosky Steven T, Lopez Oscar L, Feingold Eleanor, Kamboh M Ilyas

Abstract excerpt

Apolipoprotein E (APOE) allele 4 (APOE4), one of the robust genetic risk factors for AD, has also been associated with cognitive decline in terms of memory, executive function, language, and global cognitive function. APOE genotype-stratified analysis can help to identify additional genetic loci which might be masked due to a strong effect of APOE4. We conducted a genome-wide meta-analysis in APOE2 carriers,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40725187
DOI: 10.3390/ijms26146940
PMCID: PMC12295717

Genes

APOE
DTWD2
IL1RL2
KCNN2
RASEF
YTHDC2

Provenance

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