Article
FBXW7 mutations reprogram glucose metabolism by activating the ETV6-GLUT1 axis.
Molecular cancer - 14 Feb 2026
Fei Siqi, Xu Xiayun, Wang Tingrui, Jiang Xinyue, Zhu Hanrong, Chen Yingji, Yuan Renjie, Lv Zeheng, Gao Zhijian, Liu Huanxin, Chen Xiaojun, Wang Chenji, Gao Kun
Abstract excerpt
The progression of endometrial cancer (EC) involves substantial metabolic reprogramming, frequently driven by mutations in tumor suppressors and oncogenes. In this study, we identify a previously unrecognized pathway through which FBXW7 mutations rewire glucose metabolism in EC cells. Specifically, we demonstrate that loss-of-function mutations in FBXW7 disrupt the SCFFBXW7 E3 ubiquitin ligase complex, resulting...
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