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Targeting fructose metabolism for cancer therapy

15 Jul 2025

Abstract excerpt

Cancer cells frequently rewire their metabolism to support rapid proliferation and invasion. Our analysis of the most lethal cancers in 2022 reveals a prominent association with dysregulated fructose metabolism. Fructose serves as a crucial alternative energy substrate under nutrient-deprived conditions, promoting the Warburg effect and thereby facilitating tumor growth and metastasis. Moreover, aberrant fructose...

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PMID: 40653188
DOI: 10.1016/j.canlet.2025.217914

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