Article
Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018
Davis Ryan J, Gönen Mehmet, Margineantu Daciana H, Handeli Shlomo, Swanger Jherek, Hoellerbauer Pia, Paddison Patrick J, Gu Haiwei, Raftery Daniel, Grim Jonathan E, Hockenbery David M, Margolin Adam A, Clurman Bruce E
Abstract excerpt
The Fbw7 (F-box/WD repeat-containing protein 7) ubiquitin ligase targets multiple oncoproteins for degradation and is commonly mutated in cancers. Like other pleiotropic tumor suppressors, Fbw7's complex biology has impeded our understanding of how Fbw7 mutations promote tumorigenesis and hindered the development of targeted therapies. To address these needs, we employed a transfer learning approach to derive...
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