Article

PMM2 controls ERα levels and cell proliferation in ESR1 Y537S variant expressing breast cancer cells

2023-06-12

Abstract excerpt

<h4>Purpose: </h4> Metabolic reprogramming in breast cancer (BC) subtypes offers potential personalized treatment targets. Estrogen receptor α (ERα)-positive BC patients undergoing endocrine therapy (ET) can develop ET-resistant metastatic disease. Specific mutations, like Y537S in ERα, drive uncontrolled metastatic cell proliferation. Targeting mutant receptor levels shows promise for inhibiting growth in metasta...

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Literature Corpus work: 8911b4b7-31b4-53b1-813e-a9af6b62ca99
DOI: 10.21203/rs.3.rs-3034459/v1

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