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Article

FBXW7 in breast cancer: mechanism of action and therapeutic potential

2 Sept 2023

Abstract excerpt

Breast cancer is one of the frequent tumors that seriously endanger the physical and mental well-being in women. F-box and WD repeat domain-containing 7 (FBXW7) is a neoplastic repressor. Serving as a substrate recognition element for ubiquitin ligase, FBXW7 participates in the ubiquitin-proteasome system and is typically in charge of the ubiquitination and destruction of crucial oncogenic proteins, further...

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PMID: 37658431
DOI: 10.1186/s13046-023-02767-1

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