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Article

Mitochondrial dysfunction in the pathogenesis of intervertebral disc herniation: a mitochondrial related genome-wide Mendelian randomization analysis.

Journal of translational medicine - 14 Feb 2026

Wang Yihao, Bie Yongchen, Zhang Yun, Huang Ying, Wu Kaili, Ma Xuexiao, Li Yan

Abstract excerpt

BACKGROUND: As a degenerative disease, the pathophysiology of intervertebral disc herniation (IDH) closely related to mitochondrial dysfunction. However, the specific molecular mechanisms involved have yet to be precisely established. METHODS: Here, we employed a two-sample, two-step Mendelian Randomization (MR) approach, along with summary-Data-Based MR, genetic colocalization, full phenomenon association...

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Topics

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Share to DMPK gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Intervertebral Disc Displacement

Share to Mendelian Randomization Analysis

Share to Mitochondria

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41691216
DOI: 10.1186/s12967-026-07851-6
PMCID: PMC13011563

Genes

DMPK
EHHADH
METTL17
NDUFA13
TUFM
ME3
SLC25A16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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