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Article

Mitochondria-Related Genome-Wide Mendelian Randomization Identifies Putatively Causal Genes for Neurodegenerative Diseases.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2025

Wang Zheyi, Sun Yize, Bai Zetai, Li Mei, Kong Deyuan, Wu Guanzhao

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction is increasingly recognized as a key factor in neurodegenerative diseases (NDDs), underscoring the therapeutic potential of targeting mitochondria-related genes. This study aimed to identify novel biomarkers and drug targets for these diseases through a comprehensive analysis that integrated genome-wide Mendelian randomization (MR) with genes associated with mitochondrial...

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Identifiers

PMID: 39838927
DOI: 10.1002/mds.30123

Genes

ACLY
BCKDK
DMPK
LACTB2
MALSU1
MCL1
NDUFAF2
TOP3A
VWA8

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