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Unveiling therapeutic targets for spinal stenosis from genetic insights: a Mendelian randomization analysis.

Scientific reports - 24 Nov 2024

Fan Zhaopeng, Chen Bohong, Ding Le, Guo Hua

Abstract excerpt

Spinal stenosis is a commonly chronic spinal degenerative disease, which is a major cause of pain and dysfunction in the elderly. Mendelian randomization (MR) has been widely applied to repurpose licensed drugs and identify novel therapeutic targets. Consequently, we intended to identify new therapeutic targets for spinal stenosis and to analyze their possible mechanisms and potential side effects.We conducted...

Topics

Humans
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Spinal Stenosis
Quantitative Trait Loci
Genome-Wide Association Study
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39582071
DOI: 10.1038/s41598-024-80697-4
PMCID: PMC11586425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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