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Article

Exploring spinal degenerative diseases therapy targets through druggability genes: a Mendelian randomization study.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2026

Qin Hao, Hao Mingyu, Wang Zhitan, Zhang Jing, Xie Minghao, Diao Yuhang, Hu Xiaojun, Rong Hongtao, Zhu Tao

Abstract excerpt

As society ages, the prevalence of spinal degenerative diseases (SDDs) is rising, creating significant life and financial burdens for patients and their families. This study employs mendelian randomization (MR) to identify therapeutic targets for SDDs management. Two sample mendelian randomization (TSMR) analyses were conducted to investigate the causal relationships between multiple genes and various SDDs,...

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Identifiers

PMID: 41922821
DOI: 10.1007/s00210-026-05275-z

Genes

ESR1
HTT
PIK3C2A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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