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Article

Mitochondrial dysfunction and onset of type 2 diabetes along with its complications: a multi-omics Mendelian randomization and colocalization study.

Frontiers in endocrinology - 1 Jan 2024

Li Yang, Miao Yahu, Feng Qing, Zhu Weixi, Chen Yijing, Kang Qingqing, Wang Zhen, Lu Fangting, Zhang Qiu

Abstract excerpt

Background: Mitochondrial dysfunction plays a crucial role in Type 2 Diabetes Mellitus (T2DM) and its complications. However, the genetic pathophysiology remains under investigation. Through multi-omics Mendelian Randomization (MR) and colocalization analyses, we identified mitochondrial-related genes causally linked with T2DM and its complications. Methods: Summary-level quantitative trait loci data at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39280009
DOI: 10.3389/fendo.2024.1401531
PMCID: PMC11392782

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