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Article

Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study.

Calcified tissue international - 1 Mar 2024

Zhao Jie, Wang Jingyu, Xu Haixu, Hu Wei, Shi Fangyuan, Fan Zhengrui, Zhou Chunlei, Mu Hong

Abstract excerpt

This study aimed to investigate the causal relationship between bone mineral density (BMD) and intervertebral disk degeneration (IVDD) using a two-sample bidirectional Mendelian randomization analysis. Summary-level data from the Genome-Wide Association Study (GWAS) were used. Instrumental variables (IVs) for IVDD were selected from the large-scale Genome-Wide Association Study (GWAS) (20,001 cases and 164,682...

Topics

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Bone Density
Causality
Genome-Wide Association Study
Intervertebral Disc Degeneration
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 37978069
DOI: 10.1007/s00223-023-01165-1
PMCID: PMC10902056

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