The causal relationship and metabolic mediation between telomere length and intervertebral disc degeneration: A two-stage network Mendelian randomization study.

Abstract excerpt

Intervertebral disc degeneration (IVDD) is a common degenerative spinal disorder and a major contributor to low back pain. Although aging is a key risk factor, the causal role of biological aging markers, such as telomere length (TL), in IVDD remains unclear. Moreover, the metabolic pathways underlying this association are largely unexplored. This study employed a 2-sample Mendelian randomization (MR) framework...

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