Article
Association of germline variants with KRAS-mutation status in colorectal cancer.
Scientific reports - 13 Feb 2026
Tjader Nijole Pollock, Ramroop Johnny, Gandhi Tanish, Dauch Cara, Meadows Owen, Stevens Patrick, Pearlman Rachel, Hampel Heather, Aglago Elom K, Berndt Sonja I, Bloomer Amanda, Brenner Hermann, Buchanan Daniel D, Campbell Peter T, Cao Yin, Chan Andrew T, Cheng Iona, Dimou Niki, Drew David A, French Amy J, Georgeson Peter, Giannakis Marios, Giles Graham G, Gomez Maria, Gruber Stephen B, Hoffmeister Michael, Huang Wen-Yi, Hullar Meredith A J, Huyghe Jeroen R, Loroña Nicole, Moreno Victor, Newton Christina C, Nowak Jonathan A, Obón-Santacana Mireia, Ogino Shuji, Pellatt Andrew, Peoples Anita R, Permuth Jennifer B, Schmit Stephanie L, Schoen Robert E, Siegel Erin M, Steinfelder Robert S, Sun Wei, Teer Jamie K, Thomas Claire E, Trinh Quang M, Tsilidis Konstantinos, Ugai Tomotaka, Um Caroline Y, Van Guelpen Bethany, Zaidi Syed H, Figueiredo Jane, Peters Ulrike, Phipps Amanda I, McElroy Joseph Paul, Toland Amanda Ewart
Abstract excerpt
Somatic mutations in KRAS are a common driver of colorectal cancer (CRC) and present at different frequencies by race, sex, tumor site, ethnicity, and genetic similarity. Inherited germline variants may influence tumor somatic mutation frequency by altering mutation or DNA repair processes or altering cellular, immunological and/or microenvironmental responses after a mutation. We hypothesized that the germline...
Read the complete abstract on PubMed