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Article

Next-Generation Sequencing-Based Detection of KRAS G12D Variants in Colorectal Cancer: A Retrospective Cohort Study.

Genes - 31 Jan 2026

Hekimoglu Gulam, Eser Metin, Yarar Murat Hakki, Ayranci Fatma Gulcicek, Ozcelik Melike

Abstract excerpt

Purpose: Colorectal cancer (CRC) is a highly aggressive malignancy of the digestive system. Somatic variants in the Kirsten rat sarcoma virus oncogene homolog (KRAS) gene have a significant influence on CRC progression and serve as key predictors of resistance to anti-epidermal growth factor receptor (EGFR) therapy. This study aimed to determine the prevalence of KRAS variants, with a particular focus on G12D...

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Source

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Identifiers

PMID: 41751558
DOI: 10.3390/genes17020174
PMCID: PMC12941330

Genes

KRAS
EGFR
ERBB2

Variants

Provenance

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Next-Generation Sequencing-Based Detection of KRAS G12D Variants in Colorectal Cancer: A Retrospective Cohort Study.PMID 41751558Read ↗

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