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Article

Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses.

PloS one - 1 Jan 2026

Ishaq Saqib, Ali Aizaz, Habib Obaid, Usmani Shabir Ahmad, Rehman Irshad Ur, Aziz Abdul, Ali Yasir, Ahmad Ajaz, Ullah Amin

Abstract excerpt

BACKGROUND: KRAS is among the most frequently mutated oncogenes in pancreatic, colorectal, and lung cancers, yet the structural and dynamic mechanisms by which specific coding variants alter its function remain poorly understood. This study employs an extensive in-silico protocol to identify the most detrimental non-synonymous single nucleotide polymorphisms (nsSNPs) within the KRAS gene. OBJECTIVE: To identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41671225
DOI: 10.1371/journal.pone.0341219
PMCID: PMC12893532

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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