Article
Prevalence of the variant allele rs61764370 T>G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families.
Breast cancer research and treatment - 1 Jul 2011
Hollestelle Antoinette, Pelletier Cory, Hooning Maartje, Crepin Ellen, Schutte Mieke, Look Maxime, Collee J Margriet, Nieuwlaat Anja, Dorssers Lambert C J, Seynaeve Caroline, Aulchenko Yurii S, Martens John W M, van den Ouweland Ans M W, Weidhaas Joanne B
Abstract excerpt
Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families. This functional variant has been shown to disrupt a let-7 miRNA binding site leading to increased expression of KRAS in...
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