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Article

Protocol for quantifying interaction patterns among genomic alterations in cancer.

STAR protocols - 20 Mar 2026

Maqueda-Real Adrián, Ham Seokjin, Ollé-Monràs Laia, Park Solip

Abstract excerpt

Publicly available large-scale cancer datasets allow for the systematic analysis of complex genomic alteration associations in tumorigenesis. Here, we present a protocol to quantify diverse interaction patterns between genomic alterations. We describe steps to prepare a binarized alteration matrix and analyze mutation-copy number alteration (CNA) associations, including pairwise, high-order, and context-dependent...

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Identifiers

PMID: 41686643
DOI: 10.1016/j.xpro.2026.104364
PMCID: PMC12915222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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