Article

Network-aware mutation clustering of cancer

2018-10-08

Abstract excerpt

The grouping of cancers across tissue boundaries is central to precision oncology, but remains a difficult problem. Here we present EPICC (Experimental Protein Interaction Clustering of Cancer), a novel technique to cluster cancer patients based on DNA mutation profile, that leverages knowledge of protein-protein interactions to reduce noise and amplify biological signal. We applied EPICC to data from The Cancer G...

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Literature Corpus work: cac410e2-3344-5681-ae6f-6462b7e05205
DOI: 10.1101/432872

Open publication

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