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Article

Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia.

International journal of environmental research and public health - 28 Oct 2021

Chen Chun-Hsin, Chen Po-Yu, Chen Cynthia Yi-An, Chiu Chih-Chiang, Lu Mong-Liang, Huang Ming-Chyi, Lin Yen-Kuang, Chen Yi-Hua

Abstract excerpt

The one-carbon metabolism pathway is a suitable candidate for studying the genetic and epigenetic factors contributing to metabolic abnormalities in patients with schizophrenia. We recruited 232 patients with schizophrenia and analyzed their serum folate, vitamin B12, and homocysteine levels and metabolic parameters to investigate the associations of genetic variants of methylenetetrahydrofolate reductase (MTHFR)...

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PMID: 34769853
DOI: 10.3390/ijerph182111333
PMCID: PMC8583146

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