Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics.

Journal of clinical psychopharmacology - 1 Apr 2012

Ellingrod Vicki L, Taylor Stephan F, Dalack Gregory, Grove Tyler B, Bly Michael J, Brook Robert D, Zöllner Sebastian K, Pop-Busui Rodica

Abstract excerpt

Folate has been implicated in cardiovascular disease with atypical antipsychotic (AAPs) use, and individuals with methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) variants are at greater risk. This study examined the relationship between the MTHFR 677C/T, MTHFR 1298A/C, and COMT Val158Met variants; metabolic syndrome; and lifestyle measures in schizophrenia and bipolar...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Bipolar Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Folic Acid

Share to Homocysteine

Share to Life Style

Share to Metabolic Syndrome

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Source

Open in PubMed Open full text

Identifiers

PMID: 22370993
DOI: 10.1097/JCP.0b013e3182485888
PMCID: PMC3622480

Genes

MTHFR
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics.PMID 22370993Read ↗

MTHFR and risk of metabolic syndrome in patients with schizophrenia.Semantic proximity Read ↗

Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.Semantic proximity Read ↗

Associations of Genetic Variants of Methylenetetrahydrofolate Reductase and Serum Folate Levels with Metabolic Parameters in Patients with Schizophrenia.Semantic proximity Read ↗

Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype.Semantic proximity Read ↗

A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia.Semantic proximity Read ↗

Association of FTO, LEPR and MTHFR gene polymorphisms with metabolic syndrome in schizophrenia patients receiving antipsychotics.Semantic proximity Read ↗

Dietary, lifestyle and pharmacogenetic factors associated with arteriole endothelial-dependent vasodilatation in schizophrenia patients treated with atypical antipsychotics (AAPs).Semantic proximity Read ↗

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.Semantic proximity Read ↗

The influence of metabolic syndrome, physical activity and genotype on catechol-O-methyl transferase promoter-region methylation in schizophrenia.Semantic proximity Read ↗

DNA methylation in schizophrenia subjects: gender and MTHFR 677C/T genotype differences.Semantic proximity Read ↗

Endothelial function, folate pharmacogenomics, and neurocognition in psychotic disorders.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase and psychiatric diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.