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Article

Lactate derived from macrophages drives skin dermal fibroblasts phenotypic remodeling via MCT1-primed histone H3 lysine 23 lactylation in hypertrophic scar.

Nature communications - 12 Feb 2026

Yuan Yixuan, Xiao Yujie, Zou Jie, Luo Liang, Li Mengyang, Shen Kuo, Wei Lai, Zhang Yihao, Wang Peng, Chen Yan, Zhuo Shixuan, Zhang Hao, Song Shijie, Jia Yanhui, Wang Kejia, Jiang Shiqing, Guan Hao, Hu Dahai

Abstract excerpt

Hypertrophic scar (HS) is a fibroproliferative disorder characterized by fibroblast hyperactivation and aberrant extracellular matrix deposition. This study identifies macrophage-derived lactate as a key mediator of fibroblast phenotypic remodeling via monocarboxylate transporter 1 (MCT1)-mediated histone H3 lysine 23 lactylation (H3K23la) in HS. Elevated lactate levels and MCT1 expression were observed in HS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41680147
DOI: 10.1038/s41467-026-69388-y
PMCID: PMC13009470

Genes

COL11A1
HEY2
SMAD2
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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